Cerebral sinus venous thrombosis in children with inherited bleeding disorders: A case series

Abstract

In patients with inherited bleeding disorders, thrombus development poses a challenge in balancing the management of thrombosis and bleeding. Pediatric antithrombotic therapy guidelines do not address the treatment of a thrombus in the setting of a bleeding disorder. We present a case series of four children with inherited bleeding disorders presenting with cerebral sinus venous thrombosis and bleeding, in order to summarize the different therapeutic approaches and outcomes of these patients.

Keywords: cerebral sinus venous thrombosis; coagulation; hemophilia; inherited bleeding disorder; von Willebrand disease.