Six-Step Continuous Flow Synthesis of Diclofenac Sodium via Cascade Etherification/Smiles Rearrangement Strategy: Tackling the Issues of Batch Processing

Lulu Wang; Minjie Liu; Meifen Jiang; Li Wan; Weijian Li; Dang Cheng; Fener Chen

doi:10.1002/chem.202202097

Six-Step Continuous Flow Synthesis of Diclofenac Sodium via Cascade Etherification/Smiles Rearrangement Strategy: Tackling the Issues of Batch Processing

Chemistry. 2022 Aug 10;28(45):e202202097. doi: 10.1002/chem.202202097. Epub 2022 Jul 26.

Authors

Lulu Wang^{1

2}, Minjie Liu^{1

2}, Meifen Jiang^{1

2}, Li Wan^{1

2}, Weijian Li^{1

2}, Dang Cheng^{1

2}, Fener Chen^{1

2}

Affiliations

¹ Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai, 200433, P. R. China.
² Shanghai Engineering Research Center of, Industrial Asymmetric Catalysis of Chiral Drugs, Shanghai, 200433, P. R. China.

PMID: 35880653
DOI: 10.1002/chem.202202097

Abstract

Invited for the cover of this issue are Dang Cheng, Fener Chen and co-workers at Fudan University. The image depicts six-step continuous-flow synthesis of diclofenac sodium from commercially available aniline and chloroacetic acid in a desktop microchemical plant. Read the full text of the article at 10.1002/chem.202201420.

MeSH terms

Diclofenac*
Humans

Substances

Diclofenac