Patent bibliometric analysis for global trend of organoid technologies in the past decade

Lili Zhu; Yuhang Fan; Xuemei Huang; Tao Chen; Xiaodong Xu; Fang Xu; Yingying Gong; Pu Chen

doi:10.1016/j.isci.2022.104728

Patent bibliometric analysis for global trend of organoid technologies in the past decade

iScience. 2022 Jul 8;25(8):104728. doi: 10.1016/j.isci.2022.104728. eCollection 2022 Aug 19.

Authors

Lili Zhu¹, Yuhang Fan¹, Xuemei Huang¹, Tao Chen¹, Xiaodong Xu¹, Fang Xu¹, Yingying Gong², Pu Chen^{1

3}

Affiliations

¹ Tissue Engineering and Organ Manufacturing (TEOM) Lab, Department of Biomedical Engineering, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Hubei 430071, China.
² Wuhan Yuchen Patent Office, Wuhan Branch of Chinese Academy of Sciences, Hubei 430072, China.
³ Hubei Key Laboratory of Embryonic Stem Cell Research (Hubei University of Medicine), Shiyan, Hubei 442099, China.

Abstract

Organoids are considered a game-changing paradigm of research models for human physiology and disease, which provides unsurpassed opportunities across disciplines in basic medical research, drug development, and personalized medicine. Here, we made a deep investigation for global patents of organoid technologies in the past decade using bibliometric analysis for the first time. We have identified a total of 672 patents related to organoid technology. The number of annual patent applications exhibits an overall upward growth trend over the past decade, especially entering an exponential growth since 2015. Notably, 76.64% of patents are related to the construction of organoid models. Liver, brain, and intestinal models take up the first three places in the physiological models, while tumor models account for 76.30% of the total patents for disease models. Furthermore, drug screening is the most preferred application, revealing the great commercial value of organoid technologies in precision medicine and preclinical drug screening.

Keywords: Bioengineering; Biological sciences; Biotechnology; Tissue engineering.