Paratyphoid Fever A: Infection and Prevention

Lei Xie; Lan Ming; Manlin Ding; Luxin Deng; Miao Liu; Yanguang Cong

doi:10.3389/fmicb.2022.945235

Paratyphoid Fever A: Infection and Prevention

Front Microbiol. 2022 Jul 8:13:945235. doi: 10.3389/fmicb.2022.945235. eCollection 2022.

Authors

Lei Xie¹, Lan Ming², Manlin Ding^{1

2}, Luxin Deng³, Miao Liu¹, Yanguang Cong^{1

2}

Affiliations

¹ Precision Medicine Center, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China.
² Department of Clinical Laboratory, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China.
³ Department of Clinical Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Abstract

Enteric fever is caused by Salmonella enterica serovar Typhi, Salmonella enterica serovar Paratyphi A, B, and C. While S. Typhi remains the primary causative agent of enteric fever, S. Paratyphi A is responsible for an increasing portion of enteric fever incidence. However, the current available vaccines for enteric fever are all developed from S. Typhi, and lack adequate cross immune protection against paratyphoid fever A. Therefore, paratyphoid A vaccines are urgently needed. The present paper reviews the latest progresses in pathogenesis, global burden, infection features of paratyphoid fever A, as well as the status of vaccine development, highlighting the necessity for the development of vaccines against paratyphoid fever A.

Keywords: Salmonella enterica serovar Paratyphi A; bivalent vaccine; enteric fever; paratyphoid fever A; vaccine.

Publication types

Review