The emergence of nanoporous materials in lung cancer therapy

Deepika Radhakrishnan; Shan Mohanan; Goeun Choi; Jin-Ho Choy; Steffi Tiburcius; Hoang Trung Trinh; Shankar Bolan; Nikki Verrills; Pradeep Tanwar; Ajay Karakoti; Ajayan Vinu

doi:10.1080/14686996.2022.2052181

The emergence of nanoporous materials in lung cancer therapy

Sci Technol Adv Mater. 2022 Jul 20;23(1):225-274. doi: 10.1080/14686996.2022.2052181. eCollection 2022.

Authors

Deepika Radhakrishnan¹, Shan Mohanan¹, Goeun Choi^{1

2

3

4}, Jin-Ho Choy^{1

2

5

6}, Steffi Tiburcius¹, Hoang Trung Trinh¹, Shankar Bolan¹, Nikki Verrills^{1

7}, Pradeep Tanwar^{1

7}, Ajay Karakoti¹, Ajayan Vinu¹

Affiliations

¹ Global Innovative Centre for Advanced Nanomaterials, College of Engineering, Science and Environment, School of Engineering, The University of Newcastle, Callaghan, NSW, 2308, Australia.
² Intelligent Nanohybrid Materials Laboratory (INML), Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea.
³ College of Science and Technology, Dankook University, Cheonan 31116, Republic of Korea.
⁴ Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Korea.
⁵ Course, College of Medicine, Dankook UniversityDepartment of Pre-medical, Cheonan 31116, Korea.
⁶ Tokyo Tech World Research Hub Initiative (WRHI), Institute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8503, Japan.
⁷ School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellness, The University of Newcastle, Callaghan, NSW, 2308, Australia.

Abstract

Lung cancer is one of the most common cancers, affecting more than 2.1 million people across the globe every year. A very high occurrence and mortality rate of lung cancer have prompted active research in this area with both conventional and novel forms of therapies including the use of nanomaterials based drug delivery agents. Specifically, the unique physico-chemical and biological properties of porous nanomaterials have gained significant momentum as drug delivery agents for delivering a combination of drugs or merging diagnosis with targeted therapy for cancer treatment. This review focuses on the emergence of nano-porous materials for drug delivery in lung cancer. The review analyses the currently used nanoporous materials, including inorganic, organic and hybrid porous materials for delivering drugs for various types of therapies, including chemo, radio and phototherapy. It also analyses the selected research on stimuli-responsive nanoporous materials for drug delivery in lung cancer before summarizing the various findings and projecting the future of emerging trends. This review provides a strong foundation for the current status of the research on nanoporous materials, their limitations and the potential for improving their design to overcome the unique challenges of delivering drugs for the treatment of lung cancer.

Keywords: Nanoporous materials; Organic nanoporous materials; drug delivery; hybrid nanomaterials; inorganic nanoporous materials; lung cancer; stimuli responsive.

Publication types

Review

Grants and funding

One of the authors A. Vinu acknowledges the research support of the University of Newcastle. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2020R1I1A2074844), and by the NRF grant funded by the Korea government (MSIT) (No. Institute of Information & communications Technology Planning & Evaluation (IITP) 2020R1F1A1075509).