Dengue Infection - Recent Advances in Disease Pathogenesis in the Era of COVID-19

Yean Kong Yong; Won Fen Wong; Ramachandran Vignesh; Indranil Chattopadhyay; Vijayakumar Velu; Hong Yien Tan; Ying Zhang; Marie Larsson; Esaki M Shankar

doi:10.3389/fimmu.2022.889196

Dengue Infection - Recent Advances in Disease Pathogenesis in the Era of COVID-19

Front Immunol. 2022 Jul 6:13:889196. doi: 10.3389/fimmu.2022.889196. eCollection 2022.

Authors

Yean Kong Yong¹, Won Fen Wong², Ramachandran Vignesh³, Indranil Chattopadhyay⁴, Vijayakumar Velu^{5

6}, Hong Yien Tan⁷, Ying Zhang⁸, Marie Larsson⁹, Esaki M Shankar¹⁰

Affiliations

¹ Laboratory Centre, Xiamen University Malaysia, Sepang, Malaysia.
² Department of Medical Microbiology, Faculty Medicine, University of Malaya, Kuala Lumpur, Malaysia.
³ Preclinical Department, Royal College of Medicine Perak (UniKL RCMP), Universiti Kuala Lumpur, Ipoh, Malaysia.
⁴ Cancer and Microbiome Biology, Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur, India.
⁵ Division of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States.
⁶ Department of Pathology and Laboratory Medicine, Emory National Primate Research Center, Emory University, Atlanta GA, United States.
⁷ School of Traditional Chinese Medicine, Xiamen University Malaysia, Sepang, Malaysia.
⁸ Chemical Engineering, Xiamen University Malaysia, Sepang, Malaysia.
⁹ Molecular Medicine and Virology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
¹⁰ Infection Biology, Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur, India.

Abstract

The dynamics of host-virus interactions, and impairment of the host's immune surveillance by dengue virus (DENV) serotypes largely remain ambiguous. Several experimental and preclinical studies have demonstrated how the virus brings about severe disease by activating immune cells and other key elements of the inflammatory cascade. Plasmablasts are activated during primary and secondary infections, and play a determinative role in severe dengue. The cross-reactivity of DENV immune responses with other flaviviruses can have implications both for cross-protection and severity of disease. The consequences of a cross-reactivity between DENV and anti-SARS-CoV-2 responses are highly relevant in endemic areas. Here, we review the latest progress in the understanding of dengue immunopathogenesis and provide suggestions to the development of target strategies against dengue.

Keywords: COVID-19; antibody-dependent enhancement (ADE); cytokine storm; dengue (DENV); endothelial dysfunction; inflammasome; pathogenesis; plasmablasts.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Viral
Antibody-Dependent Enhancement
COVID-19*
Dengue Virus*
Dengue*
Humans

Substances

Antibodies, Viral

Abstract

Publication types

MeSH terms

Substances

Grants and funding