Non-homologous use of adipose-derived cell and tissue therapies: Osteoarthritis as a case study

Trivia Frazier; Keith March; Jaime R Garza; Bruce A Bunnell; Kevin F Darr; Emma Rogers; Katie Hamel; Jeffrey M Gimble

doi:10.1016/j.bonr.2022.101601

Non-homologous use of adipose-derived cell and tissue therapies: Osteoarthritis as a case study

Bone Rep. 2022 Jul 6:17:101601. doi: 10.1016/j.bonr.2022.101601. eCollection 2022 Dec.

Authors

Trivia Frazier^{1

2}, Keith March³, Jaime R Garza^{2

4}, Bruce A Bunnell⁵, Kevin F Darr⁶, Emma Rogers¹, Katie Hamel¹, Jeffrey M Gimble^{1

2}

Affiliations

¹ Obatala Sciences, New Orleans, LA, United States of America.
² Tulane University, New Orleans, LA, United States of America.
³ University of Florida, Gainesville, FL, United States of America.
⁴ University of Texas Health Sciences Center - San Antonio, San Antonio, TX, United States of America.
⁵ University of North Texas Health Science Center, Ft. Worth, TX, United States of America.
⁶ Covington Orthopedics Sports Medicine Institute, Covington, LA, United States of America.

Abstract

Adipose tissue is widely recognized as an abundant and accessible human tissue that serves as a source of cells and extracellular matrix scaffolds for regenerative surgical applications. Increasingly, orthopedic surgeons are turning to adipose tissue as a resource in their treatment of osteoarthritis and related conditions. In the U.S., the regulatory landscape governing the orthopedic surgical utilization of autologous and allogeneic adipose tissue remains complex. This manuscript reviews the Food and Drug Administration's nomenclature and guidance regarding adipose tissue products. Additionally, it surveys recent pre-clinical and clinical trial literature relating to the application of adipose-derived cells and tissues in the treatment of osteoarthritis.

Keywords: ASC, Adipose Stromal/Stem Cells; Adipose; CBER, Center for Biologics Evaluation and Research; HCT/P, Human Cells, Tissues, and Cell/Tissue related Products; MFAT, MicroFragmented Adipose Tissue; Microfragmented fat; OA, Osteoarthritis; Osteoarthritis; Regenerative medicine; Regulatory agency; SVF, Stromal Vascular Fraction Cells; Stromal/stem cells.

Publication types

Review