Efficacy analysis of Cheng's GIRAFFE reconstruction after proximal gastrectomy for adenocarcinoma of esophagogastric junction

Zhiyuan Xu; Can Hu; Yanqiang Zhang; Ling Huang; Litao Yang; Jianfa Yu; Pengfei Yu; Jiahui Chen; Yian Du; Xiangdong Cheng

doi:10.21147/j.issn.1000-9604.2022.03.08

Efficacy analysis of Cheng's GIRAFFE reconstruction after proximal gastrectomy for adenocarcinoma of esophagogastric junction

Chin J Cancer Res. 2022 Jun 30;34(3):289-297. doi: 10.21147/j.issn.1000-9604.2022.03.08.

Authors

Zhiyuan Xu¹, Can Hu^{1

2}, Yanqiang Zhang¹, Ling Huang¹, Litao Yang¹, Jianfa Yu¹, Pengfei Yu¹, Jiahui Chen¹, Yian Du¹, Xiangdong Cheng¹

Affiliations

¹ Department of Gastric Surgery, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou 310022, China.
² Department of Gastrointestinal Surgery, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China.

PMID: 35873890
PMCID: PMC9273578
DOI: 10.21147/j.issn.1000-9604.2022.03.08

Abstract

Objective: Reconstruction of the digestive tract for adenocarcinoma of esophagogastric junction (AEG) is in dispute. This study evaluated Cheng's gastric tube interposition esophagogastrostomy with reconstruction of His angle and fundus (Cheng's GIRAFFE anastomosis) in laparoscopic/open proximal gastrectomy for Siewert type II AEG, which was performed at Zhejiang Cancer Hospital and the First Affiliated Hospital of Zhejiang Chinese Medical University. Here, we discuss the preliminary results of gastric emptying and anti-reflux.

Methods: From a retrospective database, 74 patients with advanced Siewert type II AEG underwent curative proximal gastrectomy with GIRAFFE anastomosis, and their gastric emptying and anti-reflux outcomes were evaluated by the Reflux Disease Questionnaire (RDQ) score, nuclide gastric emptying, 24-h impedance-pH monitoring and gastroscopy.

Results: Seventy-four patients successfully completed proximal partial gastrectomy with Cheng's GIRAFFE esophagogastric anastomosis. RDQ score six months after the operation was 2.2±2.5. Results of nuclide gastric emptying examinations showed that the gastric half-emptying time was 67.0±21.5 min, the 1-h residual rate was (52.2±7.7)%, the 2-h residual rate was (36.4±5.1)%, and the 3-h residual rate was (28.8±3.6)%; 24-h impedance-pH monitoring revealed that the mean DeMeester score was 5.8±2.9. Reflux esophagitis was observed by gastroscopy in 7 patients six months after surgery.

Conclusions: Cheng's GIRAFFE anastomosis is safe and feasible for Siewert type II AEG.

Keywords: Cheng’s GIRAFFE anastomosis; Siewert type II AEG; anti-reflux; proximal gastrectomy.