The Regulatory Role of Ferroptosis in Bone Homeostasis

Yuan Xiong; Lang Chen; Ze Lin; Yiqiang Hu; Adriana C Panayi; Wu Zhou; Yun Sun; Faqi Cao; Guodong Liu; Guangdong Dai; Bobin Mi; Guohui Liu

doi:10.1155/2022/3568597

The Regulatory Role of Ferroptosis in Bone Homeostasis

Stem Cells Int. 2022 Jul 13:2022:3568597. doi: 10.1155/2022/3568597. eCollection 2022.

Authors

Yuan Xiong^{1

2}, Lang Chen^{1

2}, Ze Lin^{1

2}, Yiqiang Hu^{1

2}, Adriana C Panayi³, Wu Zhou^{1

2}, Yun Sun⁴, Faqi Cao^{1

2}, Guodong Liu⁵, Guangdong Dai⁶, Bobin Mi^{1

2}, Guohui Liu^{1

2}

Affiliations

¹ Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
² Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430022, China.
³ Department of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02152, USA.
⁴ Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
⁵ Medical Center of Trauma and War Injuries, Daping Hospital, Army Medical University, Chongqing 400042, China.
⁶ Pingshan District People's Hospital of Shenzhen, Pingshan General Hospital of Southern Medical University, Shenzhen, Guangdong, China 518118.

Abstract

Ferroptosis is an iron-dependent form of programmed cell death and an important type of biological catabolism. Through the action of divalent iron or ester oxygenase, ferroptosis can induce lipid peroxidation and cell death, regulating a variety of physiological processes. The role of ferroptosis in the modulation of bone homeostasis is a significant topic of interest. Herein, we review and discuss recent studies exploring the mechanisms and functions of ferroptosis in different bone-related cells, including mesenchymal stem cells, osteoblasts, osteoclasts, and osteocytes. The association between ferroptosis and disorders of bone homeostasis is also explored in this review. Overall, we aim to provide a detailed overview of ferroptosis, summarizing recent understanding on its role in regulation of bone physiology and bone disease pathogenesis.

Publication types

Review