Antioxidant activity and protective effect of methyl gallate against t-BHP induced oxidative stress through inhibiting ROS production

Bo-Im Ryu; Ki-Tae Kim

doi:10.1007/s10068-022-01120-0

Antioxidant activity and protective effect of methyl gallate against t-BHP induced oxidative stress through inhibiting ROS production

Food Sci Biotechnol. 2022 Jun 27;31(8):1063-1072. doi: 10.1007/s10068-022-01120-0. eCollection 2022 Jul.

Authors

Bo-Im Ryu¹, Ki-Tae Kim²

Affiliations

¹ Department of Applied Life Science, Konkuk University, Chungju, 27478 Korea.
² Department of Korean Medicine, Semyung University, Jecheon, 27136 Korea.

Abstract

Non-alcoholic fatty liver disease (NAFLD) is one of the major diseases of chronic liver damage caused by oxidative stress. In this study, we investigated hepatoprotective effect of methyl gallate (MG) against t-BHP induced oxidative stress. Our results revealed that MG possessed strong antioxidant activity and lipid peroxidation inhibitory activity. In addition, MG inhibited t-BHP induced cell cytotoxicity, ROS production and sub-G1 phase cells in Chang liver cells. MG attenuated also activated signal p38 and decreased mitochondrial-mediated cell death by regulating pro- and anti- apoptotic proteins. Our results indicate that MG could be potentially used as protective agent in NAFLD therapy by modulating oxidative stress.

Keywords: Methyl gallate; Oxidative stress; Protective effect; t-BHP.