Screening for and identifying patients with Parkinson's disease (PD) at an early stage and forming accurate diagnosis of PD during the course of the progression of the disease are of essential importance but still remain challenging for the clinical diagnosis and treatment of PD. One of the common clinical manifestations of PD is speech impairment, or voice impairment. Thanks to the recent advances in the field of acoustic analysis, a large number of acoustic parameters have been proposed for evaluating speech impairment quantitatively. Early identification and accurate diagnosis of PD was henceforth made possible through the application of speech acoustic analysis. Herein, we summarized the latest research findings on the application of acoustic analysis in PD diagnosis. We reported some acoustic parameters commonly used in the evaluation of voice impairment in PD patients. Then, we presented the diagnostic value of acoustic analysis in developing accurate diagnosis, early screening and differential diagnosis. Furthermore, we discussed the drawbacks and prospects of current studies, intending to enhance understanding of acoustic analysis of PD patients and its potential diagnostic values.
帕金森病临床诊疗的核心与挑战之一是如何在早期筛查识别帕金森病、如何在疾病进展期精准诊断帕金森病。帕金森病患者常出现语言障碍，即语音障碍。随着技术的发展，声学分析技术为语音评估提供了诸多客观量化的指标，也进而使得利用语音声学分析实现帕金森病的早期识别与精准诊断成为可能。本文旨在梳理帕金森病语音障碍声学分析相关研究进展，首先引入目前帕金森病语音障碍评估中常用的声学指标；并依次介绍语音声学分析在精准诊断、早期筛查及鉴别诊断的价值，同时指出目前研究缺陷及展望，以期提高对帕金森病语音声学分析及其潜在诊断价值的认识。
Keywords: Acoustic analysis; Parkinson’s disease; Speech impairment.
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