Comparing radiolytic production of H2O2 and development of Zebrafish embryos after ultra high dose rate exposure with electron and transmission proton beams

Houda Kacem; Serena Psoroulas; Gael Boivin; Michael Folkerts; Veljko Grilj; Tony Lomax; Adrien Martinotti; David Meer; Jonathan Ollivier; Benoit Petit; Sairos Safai; Ricky A Sharma; Michele Togno; Marta Vilalta; Damien C Weber; Marie-Catherine Vozenin

doi:10.1016/j.radonc.2022.07.011

Comparing radiolytic production of H₂O₂ and development of Zebrafish embryos after ultra high dose rate exposure with electron and transmission proton beams

Radiother Oncol. 2022 Oct:175:197-202. doi: 10.1016/j.radonc.2022.07.011. Epub 2022 Jul 19.

Authors

Affiliations

¹ Radiation Oncology Laboratory, Service of Radiation Oncology, Department of Oncology. Lausanne, University Hospital and University of Lausanne, Switzerland.
² Paul Scherrer Institut-Centre for Proton Therapy, Villigen, Switzerland.
³ Varian, a Siemens Healthineers Company, 3120 Hansen Way, Palo Alto, CA 94304, United States.
⁴ Institute of Radiation Physics, University Hospital and University of Lausanne, Switzerland.
⁵ Paul Scherrer Institut-Centre for Proton Therapy, Villigen, Switzerland; Institute of Radiation Physics, University Hospital and University of Lausanne, Switzerland.
⁶ Radiation Oncology Laboratory, Service of Radiation Oncology, Department of Oncology. Lausanne, University Hospital and University of Lausanne, Switzerland. Electronic address: marie-catherine.vozenin@chuv.ch.

PMID: 35868604
DOI: 10.1016/j.radonc.2022.07.011

Abstract

The physico-chemical and biological response to conventional and UHDR electron and proton beams was investigated, along with conventional photons. The temporal structure and nature of the beam affected both, with electron beam at ≥1400 Gy/s and proton beam at 0.1 and 1260 Gy/s found to be isoefficient at sparing zebrafish embryos.

Keywords: Electron FLASH; Hydrogen peroxyde; Proton FLASH; Zebrafish embryos.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Animals
Electrons
Hydrogen Peroxide
Proton Therapy*
Protons
Radiotherapy Dosage
Zebrafish*

Substances

Protons
Hydrogen Peroxide

Grants and funding

P01 CA244091/CA/NCI NIH HHS/United States