The Chemistry of HNO: Mechanisms and Reaction Kinetics

Radosław Michalski; Renata Smulik-Izydorczyk; Jakub Pięta; Monika Rola; Angelika Artelska; Karolina Pierzchała; Jacek Zielonka; Balaraman Kalyanaraman; Adam Bartłomiej Sikora

doi:10.3389/fchem.2022.930657

The Chemistry of HNO: Mechanisms and Reaction Kinetics

Front Chem. 2022 Jul 5:10:930657. doi: 10.3389/fchem.2022.930657. eCollection 2022.

Authors

Radosław Michalski¹, Renata Smulik-Izydorczyk¹, Jakub Pięta¹, Monika Rola¹, Angelika Artelska¹, Karolina Pierzchała¹, Jacek Zielonka², Balaraman Kalyanaraman², Adam Bartłomiej Sikora¹

Affiliations

¹ Institute of Applied Radiation Chemistry, Lodz University of Technology, Lodz, Poland.
² Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States.

Abstract

Azanone (HNO, also known as nitroxyl) is the protonated form of the product of one-electron reduction of nitric oxide (^•NO), and an elusive electrophilic reactive nitrogen species of increasing pharmacological significance. Over the past 20 years, the interest in the biological chemistry of HNO has increased significantly due to the numerous beneficial pharmacological effects of its donors. Increased availability of various HNO donors was accompanied by great progress in the understanding of HNO chemistry and chemical biology. This review is focused on the chemistry of HNO, with emphasis on reaction kinetics and mechanisms in aqueous solutions.

Keywords: HNO; azanone; chemical kinetics; nitroxyl; reaction mechanism.

Publication types

Review