Effect of the combinatorial iron-chelation and oxidative stress on the growth of Aspergillus species

Abstract

The growth of 14 Aspergillus strains belonging to nine species was studied under combinatorial deferriprone - H₂O₂ (iron-chelation - oxidative) stress. When deferriprone pretreated mycelia were subjected to even a weak oxidative stress, the growth inhibitory effect of iron-chelation stress was enhanced in 10 out of 14 strains. In contrast, oxidative stress pretreatment of conidia increased their deferriprone tolerance in 10 strains. Applying iron-chelators as antifungal agent or adjuvant can enhance the efficiency of the combinatorial iron withdrawal - oxidative stress strategy of our immune system and may reduce the survival of conidia escaped from the oxidative attack of pulmonary macrophages.

Keywords: Aspergilli; Aspergillus fumigatus; Combinatorial stress; Deferriprone.