Advances in Hyaluronic Acid for Biomedical Applications

Aqeela Yasin; Ying Ren; Jingan Li; Yulong Sheng; Chang Cao; Kun Zhang

doi:10.3389/fbioe.2022.910290

Advances in Hyaluronic Acid for Biomedical Applications

Front Bioeng Biotechnol. 2022 Jul 4:10:910290. doi: 10.3389/fbioe.2022.910290. eCollection 2022.

Authors

Aqeela Yasin¹, Ying Ren², Jingan Li¹, Yulong Sheng¹, Chang Cao³, Kun Zhang⁴

Affiliations

¹ School of Materials Science and Engineering, and Henan Key Laboratory of Advanced Magnesium Alloy and Key Laboratory of Materials Processing and Mold Technology (Ministry of Education), Zhengzhou University, Zhengzhou, China.
² School of Materials Science and Engineering Henan University of Technology, Zhengzhou, China.
³ Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
⁴ School of Life Science, Zhengzhou University, Zhengzhou, China.

Abstract

Hyaluronic acid (HA) is a large non-sulfated glycosaminoglycan that is the main component of the extracellular matrix (ECM). Because of its strong and diversified functions applied in broad fields, HA has been widely studied and reported previously. The molecular properties of HA and its derivatives, including a wide range of molecular weights but distinct effects on cells, moisture retention and anti-aging, and CD44 targeting, promised its role as a popular participant in tissue engineering, wound healing, cancer treatment, ophthalmology, and cosmetics. In recent years, HA and its derivatives have played an increasingly important role in the aforementioned biomedical fields in the formulation of coatings, nanoparticles, and hydrogels. This article highlights recent efforts in converting HA to smart formulation, such as multifunctional coatings, targeted nanoparticles, or injectable hydrogels, which are used in advanced biomedical application.

Keywords: coatings; hyaluronic acid; injectable hydrogels; properties and biomedical application; target nanoparticles.

Publication types

Review