TNFAIP6 Promotes Gastric Carcinoma Cell Invasion via Upregulating PTX3 and Activating the Wnt/ β-Catenin Signaling Pathway

Hongquan Cui; Ling Zhang; Bin Chen; Fengchun Zhang; Haiyan Xu; Guixiang Ma; Longnv Cao; Miao Wang

doi:10.1155/2022/5697034

TNFAIP6 Promotes Gastric Carcinoma Cell Invasion via Upregulating PTX3 and Activating the Wnt/ β-Catenin Signaling Pathway

Contrast Media Mol Imaging. 2022 Jul 6:2022:5697034. doi: 10.1155/2022/5697034. eCollection 2022.

Authors

Hongquan Cui¹, Ling Zhang¹, Bin Chen¹, Fengchun Zhang¹, Haiyan Xu¹, Guixiang Ma², Longnv Cao¹, Miao Wang²

Affiliations

¹ Oncology Department Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medicine, Suzhou 215127, China.
² Oncology Department, Siyang Hospital, Suqian 223798, China.

Abstract

Tumor metastasis is a fundamental cause of the poor prognosis of gastric carcinoma (GC). In order to study the problems affecting metastasis and recurrence of gastric cancer, the paper expose that TNF alpha induced protein 6 (TNFAIP6) is aberrantly overexpressed in GC, and patients with high-TNFAIP6 levels exhibited inferior overall survival. Mechanistically, overexpression of TNFAIP6 raised β-catenin ectopic nuclear distribution and activated the Wnt/β-catenin signal pathway. The experimental results show that TNFAIP6 facilitates the aggressive potential of GC cells through modulating PTX3 expression.

Publication types

Research Support, Non-U.S. Gov't
Retracted Publication

MeSH terms

C-Reactive Protein* / metabolism
Carcinoma*
Cell Adhesion Molecules / metabolism
Cell Line, Tumor
Cell Movement / physiology
Cell Proliferation / physiology
Humans
Neoplasm Metastasis
Serum Amyloid P-Component* / metabolism
Stomach Neoplasms* / metabolism
Stomach Neoplasms* / pathology
Tumor Necrosis Factor-alpha* / metabolism
Wnt Signaling Pathway*
beta Catenin / metabolism

Substances

Cell Adhesion Molecules
Serum Amyloid P-Component
TNFAIP6 protein, human
Tumor Necrosis Factor-alpha
beta Catenin
PTX3 protein
C-Reactive Protein