On the use of multi-objective evolutionary classifiers for breast cancer detection

PLoS One. 2022 Jul 19;17(7):e0269950. doi: 10.1371/journal.pone.0269950. eCollection 2022.

Abstract

Purpose: Breast cancer is one of the most common tumours in women, nevertheless, it is also one of the cancers that is most usually treated. As a result, early detection is critical, which can be accomplished by routine mammograms. This paper aims to describe, analyze, compare and evaluate three image descriptors involved in classifying breast cancer images from four databases.

Approach: Multi-Objective Evolutionary Algorithms (MOEAs) prove themselves as being efficient methods for selection and classification problems. This paper aims to study combinations of well-known classification objectives in order to compare the results of their application in solving very specific learning problems. The experimental results undergo empirical analysis which is supported by a statistical approach. The results are illustrated on a collection of medical image databases, but with a focus on the MOEAs' performance in terms of several well-known measures. The databases were chosen specifically to feature reliable human annotations, so as to measure the correlation between the gold standard classifications and the various MOEA classifications.

Results: We have seen how different statistical tests rank one algorithm over the others in our set as being better. These findings are unsurprising, revealing that there is no single gold standard for comparing diverse techniques or evolutionary algorithms. Furthermore, building meta-classifiers and evaluating them using a single, favorable metric is both extremely unwise and unsatisfactory, as the impact is to skew the results.

Conclusions: The best method to address these flaws is to select the right set of objectives and criteria. Using accuracy-related objectives, for example, is directly linked to maximizing the number of true positives. If, on the other hand, accuracy is chosen as the generic metric, the primary classification goal is shifted to increasing the positively categorized data points.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Breast Neoplasms* / diagnostic imaging
  • Breast Neoplasms* / genetics
  • Databases, Factual
  • Female
  • Humans
  • Mammography

Grants and funding

This work was supported by: - a grant of the Romanian National Authority for Scientific Research and Innovation, CNCS - UEFISCDI, project number PN-II-RU-TE-2014-4-1130, - a grant of the Romanian Ministry of Education and Research, CCCDI - UEFISCDI, project number PN-III-P2-2.1-PED-2019-2607, within PNCDI III and - the 2021 Development Fund of Babeș-Bolyai University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.