Model of Osteomyelitis in Rats

E N Ovchinnikov; O V Dyuryagina; M V Stogov; T A Silanteva; E A Kireeva

doi:10.1007/s10517-022-05556-6

Model of Osteomyelitis in Rats

Bull Exp Biol Med. 2022 Jul;173(3):394-397. doi: 10.1007/s10517-022-05556-6. Epub 2022 Jul 19.

Authors

E N Ovchinnikov¹, O V Dyuryagina¹, M V Stogov², T A Silanteva¹, E A Kireeva¹

Affiliations

¹ G. A. Ilizarov National Medical Research Centre for Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Kurgan, Russia.
² G. A. Ilizarov National Medical Research Centre for Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Kurgan, Russia. stogo_off@list.ru.

PMID: 35852691
DOI: 10.1007/s10517-022-05556-6

Abstract

We developed a rat model of chronic osteomyelitis of the femur caused by Staphylococcus aureus. The clinical, histomorphological, and laboratory signs were compared in rats with osteomyelitis (infected) and control animals receiving saline. On day 21 after infection, clinical, histomorphological, and laboratory signs of chronic osteomyelitis were found in experimental rats.

Keywords: Staphylococcus aureus; experimental model; femur; osteomyelitis; rats.

MeSH terms

Animals
Disease Models, Animal
Femur
Osteomyelitis* / etiology
Rats
Staphylococcal Infections*
Staphylococcus aureus