The development of technologies and therapeutic strategies is needed to combat skin infections and pathogenic microorganisms present on material surfaces that are still responsible for serious public health problems. In this study, detergents loaded with curcumin were prepared by a simple approach and characterized by UV-vis spectroscopy and fluorescence spectroscopy. Their antibacterial photodynamic effects were evaluated against Staphylococcus aureus in planktonic medium and in vivo (skin infection model), and showed a reduction up to 8 logs and 2 logs, respectively. Additionally, the curcumin-detergents were applied on photodisinfection of material surfaces such as wood, rubber, and stainless steel resulting in an efficient photoinactivation up to 3 logs. These developed detergents loaded with curcumin can improve the decontamination of material surfaces and skin infections (in vivo) when illuminated.
Keywords: Antimicrobial photodynamic therapy; Curcumin; Detergent; Photodisinfection; Surface; Wound.
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