Objective: To review the advances of the role of mitochondrial dysfunction in the spinal cord injury (SCI) and its relevant treatments.
Methods: Focusing on various mechanisms of mitochondrial dysfunction, recent relevant literature at home and abroad was identified to summarize the therapeutic strategies for SCI.
Results: Mitochondrial dysfunction is mainly manifested in abnormalities in mitochondrial energy metabolism, mitochondrial oxidative stress, mitochondrial-mediated apoptosis, mitophagy, mitochondrial permeability transition, and mitochondrial biogenesis, playing a vital role in the development of SCI. Drug that enhanced mitochondrial function have been proved beneficial for the treatment of SCI.
Conclusion: Mitochondrial dysfunction can serve as a potential therapeutic target for SCI, providing ideas and basis for the development of SCI therapeutic candidates in the future.
目的: 综述线粒体功能障碍在脊髓损伤（spinal cord injury，SCI）中的作用及相关治疗研究进展。.
方法: 查阅近年来国内外相关文献，围绕线粒体功能障碍各种机制在SCI中的作用，总结SCI的治疗策略。.
结果: 线粒体功能障碍主要表现在线粒体能量代谢、线粒体氧化应激、线粒体介导的凋亡、线粒体自噬、线粒体通透性转换以及线粒体生物合成等方面异常，在SCI发展中起着重要作用。多种增强线粒体功能的药物治疗SCI有效。.
结论: 线粒体功能障碍可以作为SCI的潜在治疗靶点，为未来SCI治疗药物的开发提供思路和依据。.
Keywords: Spinal cord injury; mitochondrial dysfunction; therapeutic strategies.