From histology to sonography in skin and superficial tissue disorders: EURO-MUSCULUS/USPRM* approach

Pathol Res Pract. 2022 Sep:237:154003. doi: 10.1016/j.prp.2022.154003. Epub 2022 Jul 3.

Abstract

Background: In clinical practice, ultrasound assessment of the skin and superficial tissues is progressively becoming a valuable diagnostic tool to support physical examination in the outpatient setting.

Objectives: The aim of this study was to define a standardized sonographic approach to (layer-by-layer) accurately evaluate multiple histological layers of the skin and superficial tissues.

Methods: Using high-frequency ultrasound probes and high-level ultrasound machines, we matched the histological microarchitecture of superficial tissues with multiple sonographic patterns in physiological and pathological conditions. Moreover, high-sensitive color/power Doppler assessments have also been performed to evaluate the microcirculation.

Results: Modern equipment allow for a detailed "sonographic dissection" of the skin and superficial tissues by evaluating different histological layers in various clinical scenarios. High-sensitive Doppler imaging clearly depicts the microvasculature, especially of pathologies.

Conclusions: In clinical practice, using adequate technological equipment, a detailed sonographic assessment of the superficial (soft) tissues can be performed with the use of high-frequency B-mode and high-sensitive Doppler imaging.

Keywords: Dermis; Doppler; Morphology; Subcutaneous fat; Ultrasound.

MeSH terms

  • Histological Techniques*
  • Humans
  • Muscles
  • Skin* / diagnostic imaging
  • Ultrasonography