Release of bioactive compounds from delivery systems by stimuli-responsive approaches; triggering factors, mechanisms, and applications

Atefe Rezaei; Fatemeh Rafieian; Safoura Akbari-Alavijeh; Mohammad Saeed Kharazmi; Seid Mahdi Jafari

doi:10.1016/j.cis.2022.102728

Release of bioactive compounds from delivery systems by stimuli-responsive approaches; triggering factors, mechanisms, and applications

Adv Colloid Interface Sci. 2022 Sep:307:102728. doi: 10.1016/j.cis.2022.102728. Epub 2022 Jul 6.

Authors

Atefe Rezaei¹, Fatemeh Rafieian², Safoura Akbari-Alavijeh³, Mohammad Saeed Kharazmi⁴, Seid Mahdi Jafari⁵

Affiliations

¹ Food Security Research Center, Department of Food Science and Technology, School of Nutrition and Food Science, Isfahan University of Medical Sciences, P.O. Box: 81746-73461, Isfahan, Iran. Electronic address: atefe.rezaei@nutr.mui.ac.ir.
² Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
³ Department of Food Science and Technology, Faculty of Agriculture and Natural Resources, University of Mohaghegh Ardabili, P.O. Box 56199-11367, Ardabil, Iran.
⁴ Faculty of Medicine, University of California, Riverside, USA.
⁵ Department of Food Materials and Process Design Engineering, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran; Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, E-32004 Ourense, Spain. Electronic address: smjafari@gau.ac.ir.

PMID: 35843031
DOI: 10.1016/j.cis.2022.102728

Abstract

Recent advances in emerging nanocarriers and stimuli-responsive (SR) delivery systems have brought about a revolution in the food and pharmaceutical industries. SR carriers are able to release the encapsulated bioactive compounds (bioactives) upon an external trigger. The potential of releasing the loaded bioactives in site-specific is of great importance for the pharmaceutical industry and medicine that can deliver the cargo in an appropriate condition. For the food industry, release of encapsulated bioactives is considerably important in processing or storage of food products and can be used in their formulation or packaging. There are various stimuli to control the favorite release of bioactives. In this review, we will shed light on the effect of different stimuli such as temperature, humidity, pH, light, enzymatic hydrolysis, redox, and also multiple stimuli on the release of encapsulated cargo and their potential applications in the food and pharmaceutical industries. An overview of cargo release mechanisms is also discussed. Furthermore, various alternatives to manipulate the controlled release of bioactives from carriers and the perspective of more progress in these SR carriers are highlighted.

Keywords: Bioactive compounds; Controlled release; Food; Pharmaceuticals; Stimuli-responsive.

Publication types

Review

MeSH terms

Drug Carriers*
Drug Delivery Systems*
Oxidation-Reduction
Temperature

Substances

Drug Carriers