The path from stem cells to red blood cells

Int J Hematol. 2022 Aug;116(2):160-162. doi: 10.1007/s12185-022-03413-w. Epub 2022 Jul 16.

Abstract

As oxygen is essential for energy production in mitochondria, a sufficient amount of oxygen should be continuously delivered to the tissues to maintain life. Therefore, the number of red blood cells which carry the oxygen is considerable, at up to 25 trillion in the body, and 2 million new red blood cells are generated per second.

Keywords: Enucleation; Erythroid differentiation; Heme; Iron; Red blood cells.

Publication types

  • Review

MeSH terms

  • Cell Differentiation
  • Erythrocytes* / metabolism
  • Erythropoiesis
  • Humans
  • Mitochondria
  • Oxygen / metabolism
  • Stem Cells*

Substances

  • Oxygen