Aiming to eliminate the hump phenomenon in a low specific speed centrifugal pump, its structural parameters were optimized using the computational fluid dynamics method. Based on the [Formula: see text] turbulence model, a 3D steady analysis of the internal flow field was carried out. The [Formula: see text] orthogonal table was established, and four structural parameters, including the impeller outlet diameter, impeller outlet width, number of blades, and blade outlet angle, were selected as influencing factors. Nine orthogonal test schemes were developed and the results were analyzed through the weight matrix analysis method, obtaining the weight of the selected factors on the test results. The optimal scheme was selected according to the weight and the weight matrix analysis results have shown that the impeller outlet width had the dominant influence on the head, shaft power, and efficiency. Further, the blade number was the main influencing factor for shaft power and efficiency. The centrifugal pump flow control test bench was built to carry out the numerical simulation and test all the prototype and optimization pump indexes. Through the external characteristic test, it can be seen that the [Formula: see text] of the optimized pump is 87.889, which is 24.89% lower than that of the prototype pump, which effectively optimizes the hump phenomenon of the centrifugal pump. The experimental results have shown that in underrated working conditions, the working performance of the optimized pump was improved significantly. The head size was reduced by 1.424%, and the efficiency was increased by 7.896%. By optimizing the structural pump parameters, its jet-wake hydraulic loss was reduced, and the head curve hump phenomenon was effectively eliminated. All the performance indexes of the optimized pump were higher than those of the prototype, verifying both the accuracy and reliability of the orthogonal test and weight matrix analysis method. Finally, obtained results provide a reference for the structural design of high-performance centrifugal pumps.
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