Mid-regional proadrenomedullin, C-terminal proendothelin-1 values, and disease course are not different in critically ill SARS-CoV-2 pneumonia patients with obesity

Int J Obes (Lond). 2022 Oct;46(10):1801-1807. doi: 10.1038/s41366-022-01184-2. Epub 2022 Jul 15.

Abstract

Background/objectives: Patients affected by obesity and Coronavirus disease 2019, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), appear to have a higher risk for intensive care (ICU) admission. A state of low-grade chronic inflammation in obesity has been suggested as one of the underlying mechanisms. We investigated whether obesity is associated with differences in new inflammatory biomarkers mid-regional proadrenomedullin (MR-proADM), C-terminal proendothelin-1 (CT-proET-1), and clinical outcomes in critically ill patients with SARS-CoV-2 pneumonia.

Subjects/methods: A total of 105 critically ill patients with SARS-CoV-2 pneumonia were divided in patients with obesity (body mass index (BMI) ≥ 30 kg/m2, n = 42) and patients without obesity (BMI < 30 kg/m2, n = 63) and studied in a retrospective observational cohort study. MR-proADM, CT-proET-1 concentrations, and conventional markers of white blood count (WBC), C-reactive protein (CRP), and procalcitonin (PCT) were collected during the first 7 days.

Results: BMI was 33.5 (32-36.1) and 26.2 (24.7-27.8) kg/m2 in the group with and without obesity. There were no significant differences in concentrations MR-proADM, CT-proET-1, WBC, CRP, and PCT at baseline and the next 6 days between patients with and without obesity. Only MR-proADM changed significantly over time (p = 0.039). Also, BMI did not correlate with inflammatory biomarkers (MR-proADM rho = 0.150, p = 0.125, CT-proET-1 rho = 0.179, p = 0.067, WBC rho = -0.044, p = 0.654, CRP rho = 0.057, p = 0.564, PCT rho = 0.022, p = 0.842). Finally, no significant differences in time on a ventilator, ICU length of stay, and 28-day mortality between patients with or without obesity were observed.

Conclusions: In critically ill patients with confirmed SARS-CoV-2 pneumonia, obesity was not associated with differences in MR-proADM, and CT-proET-1, or impaired outcome.

Trial registration: Netherlands Trial Register, NL8460.

Publication types

  • Comparative Study
  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenomedullin* / blood
  • Biomarkers / blood
  • C-Reactive Protein / analysis
  • COVID-19* / blood
  • COVID-19* / complications
  • COVID-19* / diagnosis
  • Critical Care
  • Critical Illness
  • Disease Progression
  • Endothelin-1* / blood
  • Humans
  • Obesity* / complications
  • Patient Admission
  • Peptide Fragments* / blood
  • Procalcitonin / blood
  • Prognosis
  • Protein Precursors* / blood
  • Retrospective Studies
  • SARS-CoV-2*

Substances

  • Biomarkers
  • C-terminal proendothelin-1
  • Endothelin-1
  • Peptide Fragments
  • Procalcitonin
  • Protein Precursors
  • proadrenomedullin
  • Adrenomedullin
  • C-Reactive Protein