De-stressing plaques attenuates atherosclerosis progression

Felix Sebastian Nettersheim; Klaus Ley

doi:10.1016/j.it.2022.06.008

De-stressing plaques attenuates atherosclerosis progression

Trends Immunol. 2022 Aug;43(8):601-603. doi: 10.1016/j.it.2022.06.008. Epub 2022 Jul 12.

Authors

Felix Sebastian Nettersheim¹, Klaus Ley²

Affiliations

¹ La Jolla Institute for Immunology, La Jolla, CA, USA; Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
² La Jolla Institute for Immunology, La Jolla, CA, USA; Department of Bioengineering, University of California, San Diego, San Diego, CA, USA; Immunology Center of Georgia (IMMCG), Augusta University Immunology Center of Georgia, 1410 Laney Walker Blvd, CN4315 Augusta, GA 30912, USA. Electronic address: klaus@lji.org.

Abstract

Atherogenesis is accompanied by formation of immune cell aggregates, so-called artery tertiary lymphoid organs (ATLOs), in the outermost layer of diseased arteries. In a recent study, Mohanta, Habenicht, and colleagues revealed that there are distinct interactions between ATLOs and the autonomous nervous system, which are critically implicated in atherosclerosis progression.

Keywords: ATLO; atherosclerosis; autonomous nervous system; synapse.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Comment

MeSH terms

Atherosclerosis*
Humans

Abstract

Publication types

MeSH terms

Grants and funding