T helper profile in pregnant women recovered from COVID-19

J Reprod Immunol. 2022 Sep:153:103661. doi: 10.1016/j.jri.2022.103661. Epub 2022 Jul 6.

Abstract

T helper (Th) cell subsets play distinct and important roles during pregnancy. This work was focused on investigating the Th and cytokine profile in pregnant women recovered from COVID-19. To this aim, the frequency of Th1, Th2, Th17 subsets and the level of associated cytokines were analysed in pregnant women recovered from COVID-19 and in matched non-pregnant women. Principal component analysis highlighted a significant impact of pregnancy on Th profile with an increase of ex-Th17 subset and a parallel decrease of Th1 population. These modulations may participate in both preserving the pregnancy and reducing the risk of severe infection.

Keywords: COVID-19; Pregnancy; T helper cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • COVID-19*
  • Cytokines
  • Female
  • Humans
  • Pregnancy
  • T-Lymphocyte Subsets*
  • T-Lymphocytes, Helper-Inducer
  • Th1 Cells
  • Th17 Cells
  • Th2 Cells

Substances

  • Cytokines