COVID-19 and the Assessment of Coenzyme Q10

Nadia Turton; Robert A Heaton; Iain P Hargreaves

doi:10.1007/978-1-0716-2395-4_27

COVID-19 and the Assessment of Coenzyme Q10

Methods Mol Biol. 2022:2511:355-365. doi: 10.1007/978-1-0716-2395-4_27.

Authors

Nadia Turton¹, Robert A Heaton¹, Iain P Hargreaves²

Affiliations

¹ School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK.
² School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK. I.P.Hargreaves@ljmu.ac.uk.

PMID: 35838974
DOI: 10.1007/978-1-0716-2395-4_27

Abstract

Coenzyme Q10 (CoQ10) plays an essential electron carrier role in the mitochondrial electron transfer chain (ETC) as well as being a potent antioxidant and influencing inflammatory mediators. In view of these functions, the reason why certain individuals may be more susceptible to the severe disease or long-term complications (long COVID) of COVID-19 infection may be associated with an underlying deficit in cellular CoQ10 status. Thus, our group has outlined an analytical method for the determination of cellular CoQ10 status using HPLC linked UV detection at 275 nm. This method has been utilized in patient tissue samples to investigate evidence of a CoQ10 deficiency and thus may have potential in determining the possible susceptibility of individuals to severe disease associated with COVID-19 infection or to long COVID.

Keywords: Antioxidant; COVID-19; CoQ10; Coenzyme Q10; Disease; Long COVID; Mitochondrial electron transport chain; Virus.

MeSH terms

COVID-19* / complications
COVID-19* / diagnosis
Humans
Mitochondrial Diseases
Post-Acute COVID-19 Syndrome
Ubiquinone* / analogs & derivatives
Ubiquinone* / chemistry
Ubiquinone* / metabolism

Substances

Ubiquinone
coenzyme Q10