Animal Models of Hepatocellular Carcinoma for Local-Regional Intraarterial Therapies

Vishnu M Chandra; Luke R Wilkins; David L Brautigan

doi:10.1148/rycan.210098

Animal Models of Hepatocellular Carcinoma for Local-Regional Intraarterial Therapies

Radiol Imaging Cancer. 2022 Jul;4(4):e210098. doi: 10.1148/rycan.210098.

Authors

Vishnu M Chandra¹, Luke R Wilkins¹, David L Brautigan¹

Affiliation

¹ From the Department of Radiology and Medical Imaging (V.M.C., L.R.W.) and Department of Microbiology, Immunology, and Cancer Biology (D.L.B.), University of Virginia Health Systems, 1215 Lee St, PO Box 800170, Charlottesville, VA 22908.

Abstract

Animal models play a crucial role in developing and testing new therapies for hepatocellular carcinoma (HCC), providing preclinical evidence prior to exploring human safety and efficacy outcomes. The interventional radiologist must weigh the advantages and disadvantages of various animal models available when testing a new local-regional therapy. This review highlights the currently available animal models for testing local-regional therapies for HCC and details the importance of considering animal genetics, tumor biology, and molecular mechanisms when ultimately choosing an animal model. Keywords: Animal Studies, Interventional-Vascular, Molecular Imaging-Clinical Translation, Molecular Imaging-Cancer, Chemoembolization, Liver © RSNA, 2022.

Keywords: Animal Studies; Chemoembolization; Interventional-Vascular; Liver; Molecular Imaging-Cancer; Molecular Imaging-Clinical Translation.

Publication types

Review

MeSH terms

Animals
Carcinoma, Hepatocellular* / diagnostic imaging
Carcinoma, Hepatocellular* / therapy
Chemoembolization, Therapeutic*
Humans
Liver Neoplasms* / diagnostic imaging
Liver Neoplasms* / therapy
Models, Animal
Tomography, X-Ray Computed