An N-N linked dimeric indole alkaloid from the marine sponge-associated rare actinomycetes Kocuria sp. S42

Jingwei Jia; Xiaozheng Wang; Jin Sang; Zhiyong Li; Shuangjun Lin; Zixin Deng; Tingting Huang

doi:10.1080/14786419.2022.2098496

An N-N linked dimeric indole alkaloid from the marine sponge-associated rare actinomycetes Kocuria sp. S42

Nat Prod Res. 2023 Oct-Nov;37(21):3647-3653. doi: 10.1080/14786419.2022.2098496. Epub 2022 Jul 14.

Authors

Jingwei Jia¹, Xiaozheng Wang¹, Jin Sang¹, Zhiyong Li¹, Shuangjun Lin¹, Zixin Deng¹, Tingting Huang¹

Affiliation

¹ State Key Laboratory of Microbial Metabolism, and Joint International Research Laboratory on Metabolic & Developmental Sciences, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China.

PMID: 35834673
DOI: 10.1080/14786419.2022.2098496

Abstract

Marine derived rare actinomycetes is emerging as one of the new sources for various natural products for further drug discovery. Dimeric indole alkaloids represent a group of structurally diverse natural products and N-N linkage is a special dimerization mode. Here, we report the isolation of 1,1'-([1,1'-biindole]-3,3'-diyl) bis (ethane-1,2-diol), a new tryptophan-derived indole alkaloid from the marine sponge-derived Kocuria sp. S42. The structure was established based on extensive spectroscopic analyses, including nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass (HR-ESI-MS) spectrometry. The new dimeric indole alkaloid via N-N linkage exhibits moderate antimicrobial activity.

Keywords: Kocuria sp.; N-N linked dimeric indole alkaloid; Rare actinomycetes; structure elucidation.