Advances towards Cell-Specific Gene Transfection: A Small-Molecule Approach Allows Order-of-Magnitude Selectivity

Thies Dirksmeyer; Paul Stahl; Cecilia Vallet; Shirley Knauer; Michael Giese; Carsten Schmuck; Christoph Hirschhäuser

doi:10.1002/chem.202202024

Advances towards Cell-Specific Gene Transfection: A Small-Molecule Approach Allows Order-of-Magnitude Selectivity

Chemistry. 2022 Aug 1;28(43):e202202024. doi: 10.1002/chem.202202024. Epub 2022 Jul 14.

Authors

Thies Dirksmeyer¹, Paul Stahl², Cecilia Vallet², Shirley Knauer², Michael Giese¹, Carsten Schmuck¹, Christoph Hirschhäuser¹

Affiliations

¹ Institute of Organic Chemistry, University of Duisburg-Essen, 45117, Essen, Germany.
² Institute of Biology, University of Duisburg-Essen, 45117, Essen, Germany.

PMID: 35833481
DOI: 10.1002/chem.202202024

Abstract

Invited for the cover of this issue are Christoph Hirschhäuser and his colleagues from the University of Duisburg-Essen. The image depicts a biotin-labelled transfection vector selectively channelling DNA into a cancer cell. The QR code on the label will lead you to a video abstract (https://youtu.be/OgXfBPZTKGA). Read the full text of the article at 10.1002/chem.202104618.

Publication types

Video-Audio Media

MeSH terms

DNA* / chemistry
Transfection

Substances

DNA