Epidemiology, clinical, and laboratory profile of patients with hepatitis C: A prospective, observational study from north-eastern India

Trop Doct. 2022 Oct;52(4):484-488. doi: 10.1177/00494755221110636. Epub 2022 Jul 13.

Abstract

Low and middle-income countries (LMICs) contribute to 80% of the global hepatitis C virus (HCV) infection burden. Intravenous drug use (IVDU) is not uncommon in Northeastern India, thus contributing to HCV. Its epidemiology, clinical, and laboratory profile were studied in a tertiary care centre in northeastern India.HCV patients (age >18) of either sex were prospectively assessed for demographic, virological, and genotype distributions. Most were male (M: F, 5.8:1) with a mean age of 37.1 ± 11.8 years. The most common risk factor was IVDU(77.69%), followed by concomitant alcohol use in 69.2%. Besides genotype 3 (59.2%), genotype 1 (26.1%) and genotype 6 were also common (14.6%). The demographics, liver disease severity, and biochemical parameters were similar across genotypes.

Keywords: Asia; diagnosis; hepatitis; public health.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Female
  • Genotype
  • Hepacivirus / genetics
  • Hepatitis C* / diagnosis
  • Hepatitis C* / epidemiology
  • Hepatitis C, Chronic* / complications
  • Hepatitis C, Chronic* / diagnosis
  • Hepatitis C, Chronic* / epidemiology
  • Humans
  • India / epidemiology
  • Male
  • Middle Aged
  • Prospective Studies