Role of NLRP3 Inflammasome in Rheumatoid Arthritis

Hui Yin; Na Liu; Keshav Raj Sigdel; Lihua Duan

doi:10.3389/fimmu.2022.931690

Role of NLRP3 Inflammasome in Rheumatoid Arthritis

Front Immunol. 2022 Jun 27:13:931690. doi: 10.3389/fimmu.2022.931690. eCollection 2022.

Authors

Hui Yin^{1

2}, Na Liu^{1

2}, Keshav Raj Sigdel³, Lihua Duan^{1

2}

Affiliations

¹ Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People's Hospital, Medical College of Nanchang University, Nanchang, China.
² Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China.
³ Department of Internal Medicine, Patan Academy of Health Sciences, Kathmandu, Nepal.

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by multi-articular, symmetrical and invasive arthritis resulting from immune system abnormalities involving T and B lymphocytes. Although significant progress has been made in the understanding of RA pathogenesis, the underlying mechanisms are not fully understood. Recent studies suggest that NLRP3 inflammasome, a regulator of inflammation, might play an important role in the development of RA. There have been increasing clinical and pre-clinical evidence showing the treatment of NLRP3/IL-1β in inflammatory diseases. To provide a foundation for the development of therapeutic strategies, we will briefly summarize the roles of NLRP3 inflammasome in RA and explore its potential clinical treatment.

Keywords: IL-1β; NOD-like receptor protein 3 (NLRP3); inflammasome; inflammation; rheumatoid arthritis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Arthritis, Rheumatoid*
Humans
Inflammasomes*
Inflammation
NLR Family, Pyrin Domain-Containing 3 Protein

Substances

Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein