Increase in amoxicillin resistance in Helicobacter pylori from Bulgarian patients over 15 years

Lyudmila Boyanova; Nayden Kandilarov; Petyo Hadzhiyski; Raina Gergova; Galina Gergova; Rumyana Markovska

doi:10.1016/j.diagmicrobio.2022.115746

Increase in amoxicillin resistance in Helicobacter pylori from Bulgarian patients over 15 years

Diagn Microbiol Infect Dis. 2022 Sep;104(1):115746. doi: 10.1016/j.diagmicrobio.2022.115746. Epub 2022 Jun 17.

Authors

Lyudmila Boyanova¹, Nayden Kandilarov², Petyo Hadzhiyski³, Raina Gergova⁴, Galina Gergova⁴, Rumyana Markovska⁴

Affiliations

¹ Department of Medical Microbiology, Medical University of Sofia, Sofia, Bulgaria. Electronic address: l.boyanova@hotmail.com.
² Department of General and Hepatobiliary Pancreatic Surgery, Department of Surgery, Medical University of Sofia, Sofia, Bulgaria.
³ Specialized Hospital for Active Pediatric Treatment, Medical University of Sofia, Sofia, Bulgaria.
⁴ Department of Medical Microbiology, Medical University of Sofia, Sofia, Bulgaria.

PMID: 35830779
DOI: 10.1016/j.diagmicrobio.2022.115746

Abstract

Helicobacter pylori resistance to amoxicillin has usually been rare. We traced resistance evolution in 474 strains over 15 years. Although minimum inhibitory concentrations MIC₅₀ and MIC₉₀ were similar among subgroups, the overall resistance rate (MICs, >0.125-3 mg/L) significantly increased from 4.2% in 2007-2014 to 8.9% in 2015-2021.

Keywords: Amoxicillin; Evolution; Helicobacter pylori; Minimal inhibitory concentration; Resistance.

MeSH terms

Amoxicillin / pharmacology
Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Bulgaria
Clarithromycin / pharmacology
Helicobacter Infections* / drug therapy
Helicobacter pylori*
Humans
Metronidazole / pharmacology
Microbial Sensitivity Tests

Substances

Anti-Bacterial Agents
Metronidazole
Amoxicillin
Clarithromycin