Inhibition of IRE1α RNase activity sensitizes patient-derived acute myeloid leukaemia cells to proteasome inhibitors

J Cell Mol Med. 2022 Aug;26(16):4629-4633. doi: 10.1111/jcmm.17479. Epub 2022 Jul 13.

Stuart Creedican^{1

2

3}, Claire M Robinson^{1

2}, Katarzyna Mnich^{1

2}, Md Nahidul Islam², Eva Szegezdi^{1

2}, Ruth Clifford^{4

5}, Janusz Krawczyk^{6

7}, John B Patterson⁸, Stephen P FitzGerald⁹, Mark Summers³, Ciaran Richardson³, Kenneth Martin³, Adrienne M Gorman^{1

2}, Afshin Samali^{1

2}

¹ Apoptosis Research Centre, University of Galway, Galway, Ireland.
² School of Biological and Chemical Sciences, University of Galway, Galway, Ireland.
³ Randox Teoranta, Dungloe, Co. Donegal, Ireland.
⁴ Limerick Digital Cancer Research Centre, HRI, School of Medicine, University of Limerick, Limerick, Ireland.
⁵ Department of Haematology, University Hospital Limerick, Limerick, Ireland.
⁶ School of Medicine, University of Galway, Galway, Ireland.
⁷ Department of Haematology, Galway University Hospital, Galway, Ireland.
⁸ Orinove Inc., Newbury Park, California, USA.
⁹ Randox Laboratories Ltd, Crumlin, Co. Antrim, UK.

No abstract available

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