Structural basis for endoperoxide-forming oxygenases

Takahiro Mori; Ikuro Abe

doi:10.3762/bjoc.18.71

Structural basis for endoperoxide-forming oxygenases

Beilstein J Org Chem. 2022 Jun 21:18:707-721. doi: 10.3762/bjoc.18.71. eCollection 2022.

Authors

Takahiro Mori^{1

2

3}, Ikuro Abe^{1

2}

Affiliations

¹ Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
² Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan.
³ PRESTO, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan.

Abstract

Endoperoxide natural products are widely distributed in nature and exhibit various biological activities. Due to their chemical features, endoperoxide and endoperoxide-derived secondary metabolites have attracted keen attention in the field of natural products and organic synthesis. In this review, we summarize the structural analyses, mechanistic investigations, and proposed reaction mechanisms of endoperoxide-forming oxygenases, including cyclooxygenase, fumitremorgin B endoperoxidase (FtmOx1), and the asnovolin A endoperoxygenase NvfI.

Keywords: X-ray crystallography; biosynthesis; endoperoxide; enzyme; natural products.

Publication types

Review

Grants and funding

The work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan (JSPS KAKENHI Grant Number JP16H06443, JP19K15703, JP20H00490, JP20KK0173, and JP20K22700), the New Energy and Industrial Technology Development Organization (NEDO, Grant Number JPNP20011), AMED (Grant Number JP21ak0101164), the PRESTO program from Japan Science and Technology Agency, The Uehara Memorial Foundation, Astellas Foundation for Research on Metabolic Disorders, Takeda Science Foundation, and Noda Institute for Scientific Research.