New epigenetic regulators of T cell exhaustion

Haydn Kissick; Rafi Ahmed

doi:10.1016/j.ccell.2022.06.008

New epigenetic regulators of T cell exhaustion

Cancer Cell. 2022 Jul 11;40(7):708-710. doi: 10.1016/j.ccell.2022.06.008.

Authors

Haydn Kissick¹, Rafi Ahmed²

Affiliations

¹ Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA; Winship Cancer Institute of Emory University, Atlanta, GA, USA; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: haydn.kissick@emory.edu.
² Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA; Winship Cancer Institute of Emory University, Atlanta, GA, USA; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.

PMID: 35820395
DOI: 10.1016/j.ccell.2022.06.008

Abstract

In this issue of Cancer Cell, Belk et al. perform an in vitro CRISPR screen to identify genes that regulate CD8⁺ T cell exhaustion. They find several genes related to epigenetic modification and show that by eliminating Arid1a, CD8⁺ T cells retain proliferative and cytotoxic function in vivo, leading to better anti-tumor activity.

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MeSH terms

CD8-Positive T-Lymphocytes*
Epigenesis, Genetic
Epigenomics
Humans
Neoplasms* / genetics