Prognostic role of baseline 18 F-FDG pet/CT in squamous cell carcinoma of the paranasal sinuses

Francesco Dondi; Nadia Pasinetti; Andrea Guerini; Cesare Piazza; Davide Mattavelli; Paolo Bossi; Alfredo Berruti; Marco Ravanelli; Davide Farina; Domenico Albano; Giorgio Treglia; Francesco Bertagna

doi:10.1002/hed.27145

Prognostic role of baseline ¹⁸ F-FDG pet/CT in squamous cell carcinoma of the paranasal sinuses

Head Neck. 2022 Nov;44(11):2395-2406. doi: 10.1002/hed.27145. Epub 2022 Jul 12.

Authors

Affiliations

¹ Department of Nuclear Medicine, University of Brescia and ASST Spedali Civili Brescia, Brescia, Italy.
² Department of Radiation Oncology, University of Brescia and ASST Spedali Civili Brescia, Brescia, Italy.
³ Department of Otorhinolaryngology-Head and Neck Surgery, University of Brescia and ASST Spedali Civili Brescia, Brescia, Italy.
⁴ Department of Medical Oncology, University of Brescia and ASST Spedali Civili Brescia, Brescia, Italy.
⁵ Department of Radiology, University of Brescia and ASST Spedali Civili Brescia, Brescia, Italy.
⁶ Clinic of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
⁷ Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland.
⁸ Faculty of Biology and Medicine, Università Della Svizzera Italiana, Lugano, Switzerland.

PMID: 35818852
DOI: 10.1002/hed.27145

Abstract

Background: To retrospectively investigate the prognostic role of baseline ¹⁸ F-FDG PET/CT in squamous cell carcinoma (SCC) of the paranasal sinuses.

Methods: Clinical features and PET/CT semiquantitative parameters of 49 patients were collected. Anova and Kruskall-Wallis tests were used to assess the relationship between these parameters. Kaplan-Meier, univariate, and multivariate analysis were performed to search for independent prognostic factors for progression free (PFS) and overall survival (OS).

Results: Mean PFS was 29.95 months (SD 29.36) with relapse/progression of disease occurring in 18 patients; mean OS was 33.40 (SD 27.78) months with death occurring in 15 patients. Presence of nodal metastasis (14 subjects) was correlated with standardize uptake value (SUV) max, SUVmean, SUV/blood-pool ratio, SUV/liver ratio, metabolic tumor volume, and total lesion glycolysis. SUVmax, SUVmean, and presence of nodal metastasis resulted as independent prognostic factors for OS.

Conclusion: ¹⁸ F-FDG PET/CT semiquantitative parameters confirmed their prognostic role for SCC of paranasal sinuses.

Keywords: 18F-FDG; PET/CT; positron emission tomography; sinonasal cancer; squamous cell carcinoma.

MeSH terms

Carcinoma, Squamous Cell* / diagnostic imaging
Carcinoma, Squamous Cell* / therapy
Fluorodeoxyglucose F18
Humans
Paranasal Sinuses*
Positron Emission Tomography Computed Tomography
Prognosis
Radiopharmaceuticals
Retrospective Studies
Tumor Burden

Substances

Radiopharmaceuticals
Fluorodeoxyglucose F18