Severe acute hepatitis in children with unknown aetiology, etiology analysis and the next action

Virol Sin. 2022 Oct;37(5):778-782. doi: 10.1016/j.virs.2022.07.004. Epub 2022 Jul 9.

¹ The Fourth Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
² Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China.
³ Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China; Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Disease, Peking University People's Hospital, Beijing, 100044, China. Electronic address: lu.fengmin@hsc.pku.edu.cn.

Abstract

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MIS-C and severe acute hepatitis might share the common pathogenic mechanism.
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SARS-CoV-2 persistence throughout multiorgan and tissues.
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Relationship between COVID-19 vaccines and severe acute hepatitis worth investigating.