Adipose tissue and ovarian aging: Potential mechanism and protective strategies

Meng Wu; Yibao Huang; Qingqing Zhu; Xiaoran Zhu; Liru Xue; Jiaqiang Xiong; Ying Chen; Chuqing Wu; Yican Guo; Yinuo Li; Mingfu Wu; Shixuan Wang

doi:10.1016/j.arr.2022.101683

Adipose tissue and ovarian aging: Potential mechanism and protective strategies

Ageing Res Rev. 2022 Sep:80:101683. doi: 10.1016/j.arr.2022.101683. Epub 2022 Jul 9.

Authors

Meng Wu¹, Yibao Huang¹, Qingqing Zhu¹, Xiaoran Zhu¹, Liru Xue¹, Jiaqiang Xiong², Ying Chen¹, Chuqing Wu¹, Yican Guo¹, Yinuo Li¹, Mingfu Wu³, Shixuan Wang⁴

Affiliations

¹ National Clinical Research Center for Obstetrical and Gynecological Diseases; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China; National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, Hubei 430030, China; Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan, Hubei 430030, China.
² Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
³ National Clinical Research Center for Obstetrical and Gynecological Diseases; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China; National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, Hubei 430030, China; Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan, Hubei 430030, China. Electronic address: mingfuwutj@163.com.
⁴ National Clinical Research Center for Obstetrical and Gynecological Diseases; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China; National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, Hubei 430030, China; Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan, Hubei 430030, China. Electronic address: sxwang@tjh.tjmu.edu.cn.

PMID: 35817297
DOI: 10.1016/j.arr.2022.101683

Abstract

Ovarian aging occurs approximately 10 years prior to the natural age-associated functional decline of other organ systems. With the increase of life expectancy worldwide, ovarian aging has gradually become a key health problem among women. Therefore, understanding the causes and molecular mechanisms of ovarian aging is very essential for the inhibition of age-related diseases and the promotion of health and longevity in women. Recently, studies have revealed an association between adipose tissue (AT) and ovarian aging. Alterations in the function and quantity of AT have profound consequences on ovarian function because AT is central for follicular development, lipid metabolism, and hormonal regulation. Moreover, the interplay between AT and the ovary is bidirectional, with ovary-derived signals directly affecting AT biology. In this review, we summarize the current knowledge of the complex molecular mechanisms controlling the crosstalk between the AT and ovarian aging, and further discuss how therapeutic targeting of the AT can delay ovarian aging.

Keywords: Adipose tissue; Obesity; Ovarian aging; Potential mechanism; Protective strategies.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Adipose Tissue* / metabolism
Aging / physiology
Female
Humans
Lipid Metabolism
Longevity
Ovary* / metabolism