A comparison of conventional and advanced electroanalytical methods to detect SARS-CoV-2 virus: A concise review

Chemosphere. 2022 Nov;307(Pt 1):135645. doi: 10.1016/j.chemosphere.2022.135645. Epub 2022 Jul 8.

Abstract

Respiratory viruses are a serious threat to human wellbeing that can cause pandemic disease. As a result, it is critical to identify virus in a timely, sensitive, and precise manner. The present novel coronavirus-2019 (COVID-19) disease outbreak has increased these concerns. The research of developing various methods for COVID-19 virus identification is one of the most rapidly growing research areas. This review article compares and addresses recent improvements in conventional and advanced electroanalytical approaches for detecting COVID-19 virus. The popular conventional methods such as polymerase chain reaction (PCR), loop mediated isothermal amplification (LAMP), serology test, and computed tomography (CT) scan with artificial intelligence require specialized equipment, hours of processing, and specially trained staff. Many researchers, on the other hand, focused on the invention and expansion of electrochemical and/or bio sensors to detect SARS-CoV-2, demonstrating that they could show a significant role in COVID-19 disease control. We attempted to meticulously summarize recent advancements, compare conventional and electroanalytical approaches, and ultimately discuss future prospective in the field. We hope that this review will be helpful to researchers who are interested in this interdisciplinary field and desire to develop more innovative virus detection methods.

Keywords: Detection; Electrochemical biosensor; Modified electrode; Point of care; Polymerase chain reaction; SARS-CoV-2.

Publication types

  • Review

MeSH terms

  • Artificial Intelligence
  • COVID-19* / diagnosis
  • Humans
  • Nucleic Acid Amplification Techniques / methods
  • Pandemics
  • SARS-CoV-2*
  • Sensitivity and Specificity