Gastrointestinal Complications of Intra-Abdominal Desmoid Tumors: A Case Report and Review of the Literature

Darcy Morris; Raquel Gonzalez; Jane Cook; Jonathan Metts; Peter Shaw

doi:10.1159/000522441

Gastrointestinal Complications of Intra-Abdominal Desmoid Tumors: A Case Report and Review of the Literature

Case Rep Oncol. 2022 May 12;15(2):515-521. doi: 10.1159/000522441. eCollection 2022 May-Aug.

Authors

Darcy Morris¹, Raquel Gonzalez², Jane Cook³, Jonathan Metts⁴, Peter Shaw⁴

Affiliations

¹ Office of Medical Education, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA.
² Division of Pediatric Surgery, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA.
³ Division of Radiology, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA.
⁴ Cancer and Blood Disorders Institute, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA.

Abstract

A 15-year-old male with a mesenteric desmoid tumor and underlying familial adenomatous polyposis presented 2 weeks after initiating sorafenib with severe abdominal pain and chills and was found to have an acute abdomen. Exploratory laparotomy revealed a necrotic, ruptured tumor with impending small bowel obstruction. The patient was later able to resume sorafenib and experienced sustained a radiographic response. It is possible that sorafenib toxicity contributed to tumor rupture yet later provided clinical benefit. Here we review the gastrointestinal complications that are associated with intra-abdominal desmoid tumors and their therapies.

Keywords: Bowel obstruction; Case report; Desmoid tumor; Tumor perforation.

Publication types

Case Reports