Current understanding of MSC-derived exosomes in the management of knee osteoarthritis

Madhan Jeyaraman; Sathish Muthu; Syed Shehabaz; Naveen Jeyaraman; Ramya Lakshmi Rajendran; Chae Moon Hong; Arulkumar Nallakumarasamy; Rathinavelpandian Perunchezhian Packkyarathinam; Shilpa Sharma; Rajni Ranjan; Manish Khanna; Byeong-Cheol Ahn; Prakash Gangadaran

doi:10.1016/j.yexcr.2022.113274

Current understanding of MSC-derived exosomes in the management of knee osteoarthritis

Exp Cell Res. 2022 Sep 15;418(2):113274. doi: 10.1016/j.yexcr.2022.113274. Epub 2022 Jul 8.

Affiliations

¹ Department of Orthopaedics, Faculty of Medicine - Sri Lalithambigai Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai, 600095, Tamil Nadu, India; Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, 201310, Uttar Pradesh, India; Indian Stem Cell Study Group (ISCSG) Association, Lucknow, 226010, Uttar Pradesh, India.
² Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, 201310, Uttar Pradesh, India; Indian Stem Cell Study Group (ISCSG) Association, Lucknow, 226010, Uttar Pradesh, India; Department of Orthopaedics, Government Medical College and Hospital, Dindigul, 624304, Tamil Nadu, India.
³ Indian Stem Cell Study Group (ISCSG) Association, Lucknow, 226010, Uttar Pradesh, India; Orthopaedic Rheumatology, Dr. RML National Law University, Lucknow, 226010, Uttar Pradesh, India.
⁴ Indian Stem Cell Study Group (ISCSG) Association, Lucknow, 226010, Uttar Pradesh, India; Orthopaedic Rheumatology, Dr. RML National Law University, Lucknow, 226010, Uttar Pradesh, India; Joint Replacement, Department of Orthopaedics, Atlas Hospitals, Tiruchirappalli, 620002, Tamil Nadu, India. Electronic address: naveenjeyaraman@yahoo.com.
⁵ Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, 41944, Republic of Korea.
⁶ Department of Orthopaedics, All India Institute of Medical Sciences, Bhubaneswar, 751019, Odissa, India.
⁷ Department of Orthopaedics, Government Medical College, Omandurar Government Estate, Chennai, 600002, Tamil Nadu, India.
⁸ Indian Stem Cell Study Group (ISCSG) Association, Lucknow, 226010, Uttar Pradesh, India; Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi, 110029, India.
⁹ Department of Orthopaedics, School of Medical Sciences and Research, Sharda University, Greater Noida, 201310, Uttar Pradesh, India.
¹⁰ Indian Stem Cell Study Group (ISCSG) Association, Lucknow, 226010, Uttar Pradesh, India; Department of Orthopaedics, Prasad Institute of Medical Sciences, Lucknow, 226401, Uttar Pradesh, India.
¹¹ Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, 41944, Republic of Korea; BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Sciences, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea. Electronic address: abc2000@knu.ac.kr.
¹² Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, 41944, Republic of Korea; BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Sciences, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea. Electronic address: prakashg@knu.ac.kr.

PMID: 35810774
DOI: 10.1016/j.yexcr.2022.113274

Abstract

Mesenchymal stem cell-derived exosomes (MSC-Exos) have been utilized as medicinal agents or as delivery vehicles in cartilage injuries and cartilage-based diseases. Given the ongoing emergence of evidence on the effector mechanisms and methods of the utility of the MSC-Exos in knee osteoarthritis, a comprehensive review of the current evidence is the need of the hour. Hence, in this article, we review the current understanding of the role of MSC-Exos in the management of knee osteoarthritis in view of their classification, characterization, biogenesis, mechanism of action, pathways involved in their therapeutic action, in-vitro evidence on cartilage regeneration, in-vivo evidence in OA knee models and recent advances in using MSC-Exos to better streamline future research from bench to bedside for OA knee.

Keywords: Cellular therapy; Exosomes; Extracellular vesicles; Knee; Mesenchymal stem cells; Osteoarthritis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cartilage
Chondrocytes / metabolism
Exosomes* / metabolism
Humans
Mesenchymal Stem Cells* / metabolism
Osteoarthritis, Knee* / metabolism
Osteoarthritis, Knee* / therapy