Imaging moiety-directed co-assembly for biodegradation control with synchronous four-modal biotracking

Qingsong Liu; Ye Fu; Bin Wu; Jingyu Tang; Yaoben Wang; Yanping Wu; Man Zhang; Shen Shen; Yang Shen; Caiyun Gao; Jiandong Ding; Liangliang Zhu

doi:10.1016/j.biomaterials.2022.121665

Imaging moiety-directed co-assembly for biodegradation control with synchronous four-modal biotracking

Biomaterials. 2022 Aug:287:121665. doi: 10.1016/j.biomaterials.2022.121665. Epub 2022 Jul 4.

Authors

Qingsong Liu¹, Ye Fu¹, Bin Wu¹, Jingyu Tang¹, Yaoben Wang¹, Yanping Wu², Man Zhang¹, Shen Shen¹, Yang Shen¹, Caiyun Gao¹, Jiandong Ding³, Liangliang Zhu⁴

Affiliations

¹ State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200438, China.
² State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Jiangsu, Nanjing, 210023, China.
³ State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200438, China. Electronic address: jdding1@fudan.edu.cn.
⁴ State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200438, China. Electronic address: zhuliangliang@fudan.edu.cn.

PMID: 35809403
DOI: 10.1016/j.biomaterials.2022.121665

Abstract

The complexity of existing methods for biodegradation control limits the multi-functionality of biomedical materials. It is urgent to develop simple and straightforward strategies to control the biodegradation rate with precise tracking of various parameters in real-time. Here, we show an imaging moiety-directed co-assembly strategy, in which different imaging moieties bearing non-covalent interaction sites are covalently introduced into the poly (D,l-lactic acid) (PDLLA) chain as end groups, followed by alternate non-covalent interactions with polymer chains upon compression molding. This strategy takes advantage of a variety of bonding types (including CH-π, CH-F, etc.) to firmly integrate the PDLLA chains and strongly control the biodegradation rate, making the amorphous prototype degraded much slower than higher-molecular-weight counterparts, and the local inflammatory response is insignificant. On this basis, a synchronous four-modal (X-ray computed tomography + fluorescence + photoacoustics + ultrasound) imaging was achieved on the single entity in vivo, even within a millimeter-scale thick-skin tissue. These imaging signals can precisely correlate the multi parameter variation trend of material mass, volume and molecular weight, signifying that co-assembly can be utilized to develop advanced theranostic systems. SINGLE SENTENCE SUMMARY: We developed an imaging moiety-directed co-assembly strategy to control the biodegradation rate and achieve the synchronization of real-time four-modal imaging in vivo. These imaging signals can precisely correlate the multi-parameter variation trend of material mass, volume and molecular weight, which provided comprehensive biomedical information accessing both qualitatively and quantitatively.

Keywords: Biodegradation; Bioinformation correlation; Biomedical polymer; Directed co-assembly; Multi-mode imaging.