Factors Influencing Dechlorane plus Distributions in Various Sheep Tissues

Int J Environ Res Public Health. 2022 Jun 29;19(13):8004. doi: 10.3390/ijerph19138004.

Abstract

Dechlorane plus (DP) is a potential persistent organic pollutant and its distribution in various tissues and organs of terrestrial organisms is currently unknown. DP concentrations in sheep tissues were determined in this study. The DP concentrations in the tissues decreased in the following order: abdominal fat > liver > stomach > heart > outer tenderloin > lung > hind leg meat > kidney > small intestine > tail fat > spleen > brain. Apart from brain and fat, anti-DP is enriched more readily than syn-DP in sheep tissues, but syn-DP is more readily enriched in brain and abdominal fat. The factors influencing DP distributions in sheep tissues were assessed by determining the DP to sheep serum albumin binding forces, binding types, and binding sites by fluorescence spectroscopy. The results indicated that anti-DP more readily binds to sheep serum albumin than does syn-DP. Therefore, sheep serum albumin will more readily transport anti-DP than syn-DP to sheep tissues, and anti-DP will be enriched more than syn-DP in the tissues. The molecular diameter of DP is the main factor affecting DP concentrations in sheep brain and fat because of the blood−brain barrier and because the main source of DP to abdominal fat is dermal contact.

Keywords: Dechlorane plus; fluorescence spectrometry; sheep serum albumin; tissues and organs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • China
  • Environmental Monitoring
  • Flame Retardants* / analysis
  • Hydrocarbons, Chlorinated* / analysis
  • Polycyclic Compounds* / analysis
  • Serum Albumin
  • Sheep

Substances

  • Flame Retardants
  • Hydrocarbons, Chlorinated
  • Polycyclic Compounds
  • Serum Albumin
  • dechlorane plus

Grants and funding

This research was funded by Fundamental Research Funds for the Central Universities, grant number 2021JCXK01; the National Development and Collaborative Innovation Center of the Minzu University of China, grant number 0910KYQN50; the Fundamental Research Fund of the Minzu University of China, grant number 2015MDTD23C and the Innovative Talent Introduction Program (111 Program) of Higher Education Institutions, grant number B08044.