NAD+ depletion and defense in bacteria

Meng Wang; Qing Ji; Peng Liu; Yukun Liu

doi:10.1016/j.tim.2022.06.002

NAD⁺ depletion and defense in bacteria

Trends Microbiol. 2023 May;31(5):435-438. doi: 10.1016/j.tim.2022.06.002. Epub 2022 Jul 5.

Authors

Meng Wang¹, Qing Ji², Peng Liu³, Yukun Liu⁴

Affiliations

¹ College of Forestry, Southwest Forestry University, Kunming 650224, Yunnan, China.
² College of Agriculture and Forestry, Puer University, Puer 665000, Yunnan, China. Electronic address: qing-ji@swfu.edu.cn.
³ Division of Biological Environmental Sciences and Engineering, King Abdullah University of Science and Technology, 23955-6900, Thuwal, Saudi Arabia.
⁴ College of Forestry, Southwest Forestry University, Kunming 650224, Yunnan, China. Electronic address: ykliu@swfu.edu.cn.

PMID: 35803784
DOI: 10.1016/j.tim.2022.06.002

Abstract

Depletion of nicotinamide adenine dinucleotide (NAD⁺), an important regulator of cellular energy metabolism, is a common strategy in immune-mediated cell death (ICD) in both prokaryotes and eukaryotes. Recent studies have revealed how bacteria use NAD⁺ depletion to protect against phages, providing insight into how eukaryotic ICD might have evolved.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacteria / genetics
Bacteria / metabolism
Cell Death
Energy Metabolism
Eukaryotic Cells*
NAD* / metabolism

Substances

NAD