Systematic review and meta-analysis of randomized, controlled trials on the effects of soy and soy products supplementation on serum adiponectin levels

Trias Mahmudiono; Nodirjon Kadirovich Khaydarov; Saade Abdalkareem Jasim; Ali Thaeer Hammid; Virgilio E Failoc-Rojas; Mohammed Nader Shalaby; Behrooz Jannat; Mehran Nouri; Abdulmnannan Fadel

doi:10.1016/j.dsx.2022.102558

Systematic review and meta-analysis of randomized, controlled trials on the effects of soy and soy products supplementation on serum adiponectin levels

Diabetes Metab Syndr. 2022 Jul;16(7):102558. doi: 10.1016/j.dsx.2022.102558. Epub 2022 Jun 28.

Authors

Trias Mahmudiono¹, Nodirjon Kadirovich Khaydarov², Saade Abdalkareem Jasim³, Ali Thaeer Hammid⁴, Virgilio E Failoc-Rojas⁵, Mohammed Nader Shalaby⁶, Behrooz Jannat⁷, Mehran Nouri⁸, Abdulmnannan Fadel⁹

Affiliations

¹ Department of Nutrition, Faculty of Public Health, Universitas Airlangga, Indonesia.
² Tashkent State Dental Institute, Makhtumkuli Street 103, Tashkent, 100047, Uzbekistan.
³ Al-maarif University College, Medical Laboratory Techniques Department, Al-anbar-Ramadi, Iraq.
⁴ Computer Engineering Techniques Department, Faculty of Information Technology, Imam Ja'afar Al-Sadiq University, Baghdad, Iraq.
⁵ Medicina basada en la evidencia, Universidad Privada Norbert Wiener, Lima, Peru.
⁶ Biological Sciences and Sports Health Department, Faculty of Physical Education, Suez Canal University, Egypt.
⁷ Halal Research Center of IRI, Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran.
⁸ Department of Community Nutrition, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: mehran_nouri71@yahoo.com.
⁹ School of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.

PMID: 35803164
DOI: 10.1016/j.dsx.2022.102558

Abstract

Background and aims: Our aim in this meta-analysis was to determine the effect of soy and soy product supplementation on serum adiponectin levels.

Method: A systematic search was conducted using Medline (PubMed and Web of Science), Scopus, and Cochrane Library for eligible trials up to August 2020. A random-effects model was used to pool calculated effect sizes.

Results: Seven trials were included in the overall analysis. Our analysis showed that soy and soy product supplementation did not significantly affect adiponectin concentrations (WMD = -0.77 μg/ml, 95% CI: -0.61, 2.15, P = 0.27) in comparison with a placebo. The between-study heterogeneity was high (I²: 68.2%, P = 0.004). Subgroup analysis, based on participants' health status and duration of the supplementation, could not detect the potential source of the observed heterogeneity. In addition, subgroup analysis showed that the effect was not statistically significant in all subgroups.

Conclusion: Overall, soy and soy product supplementation did not change the circulatory adiponectin levels. In addition, the results were not affected by the participant's health status and duration of supplementation. However, further studies are needed to confirm the present results.

Keywords: Adipokines; Adiponectin; Meta-analysis; Soy; Systematic review.

Publication types

Meta-Analysis
Review
Systematic Review

MeSH terms

Adiponectin*
Dietary Supplements*
Glycine max
Humans
Nutrients
Randomized Controlled Trials as Topic

Substances

Adiponectin