Long-circulation zwitterionic dendrimer nanodrugs for phototherapy of tumors

Xiaolei Guo; Shukai Li; Jingrui Tian; Shengfu Chen; Guanglong Ma; Haiyan Xiao; Zhiwei Liu; Longgang Wang; Xiaohua Jiang

doi:10.1016/j.colsurfb.2022.112681

Long-circulation zwitterionic dendrimer nanodrugs for phototherapy of tumors

Colloids Surf B Biointerfaces. 2022 Sep:217:112681. doi: 10.1016/j.colsurfb.2022.112681. Epub 2022 Jun 30.

Authors

Xiaolei Guo¹, Shukai Li¹, Jingrui Tian², Shengfu Chen³, Guanglong Ma⁴, Haiyan Xiao¹, Zhiwei Liu¹, Longgang Wang⁵, Xiaohua Jiang⁶

Affiliations

¹ State Key Laboratory of Metastable Materials Science and Technology, Key Laboratory of Applied Chemistry, Nano-biotechnology Key Lab of Hebei Province, Hebei Key Laboratory of Heavy Metal Deep-Remediation in Water and Resource Reuse, Yanshan University, Qinhuangdao 066004, China.
² Hebei Key Laboratory for Chronic Diseases, School of Basic Medicine, North China University of Science and Technology, Tangshan 063210, China.
³ Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
⁴ School of Pharmacy, Queen's University Belfast, Belfast, United Kingdom.
⁵ State Key Laboratory of Metastable Materials Science and Technology, Key Laboratory of Applied Chemistry, Nano-biotechnology Key Lab of Hebei Province, Hebei Key Laboratory of Heavy Metal Deep-Remediation in Water and Resource Reuse, Yanshan University, Qinhuangdao 066004, China. Electronic address: lgwang@ysu.edu.cn.
⁶ Hebei Key Laboratory for Chronic Diseases, School of Basic Medicine, North China University of Science and Technology, Tangshan 063210, China. Electronic address: xiaohua11@sina.com.

PMID: 35803033
DOI: 10.1016/j.colsurfb.2022.112681

Abstract

The development of stealth and effective antitumor nanodrugs has been drawing great attention. Herein, generation five poly(amide amine) dendrimer (G5 PAMAM) was modified by zwitterionic material carboxybetaine methacrylamide (CBMAA) on its surface to prepare zwitterionic dendrimer (G5-CBMAA_n). The results showed that G5-CBMAA₃₀ had the longest blood circulation time due to its thickest zwitterionic layer, and its residual rate after injection into mice at 2 and 12 h was as high as 47.22 % and 14.37 %, respectively. Nanodrug G5-CBMAA₃₀-ICG was prepared by containing indocyanine green (ICG) in the cavity of G5-CBMAA₃₀. G5-CBMAA₃₀-ICG had better tumor targeting ability and antitumor effect than free ICG in mice after laser irradiation, and the tumor inhibition rate was 96.6 % after 14 days' treatment. The prepared G5-CBMAA₃₀-ICG has great potential applications in the field of antitumor by phototherapy.

Keywords: Anticancer; Dendrimer; Long-circulation; Phototherapy; Zwitterionic.

MeSH terms

Animals
Dendrimers*
Indocyanine Green
Mice
Nanoparticles* / therapeutic use
Neoplasms* / drug therapy
Neoplasms* / pathology
Phototherapy / methods

Substances

Dendrimers
Indocyanine Green