Permeability of the fish intestinal membrane to bulky chemicals

Chiyoko Miyata; Yoshihide Matoba; Makiko Mukumoto; Yoshiaki Nakagawa; Hisashi Miyagawa

doi:10.1584/jpestics.D21-055

Permeability of the fish intestinal membrane to bulky chemicals

J Pestic Sci. 2022 May 20;47(2):86-92. doi: 10.1584/jpestics.D21-055.

Authors

Chiyoko Miyata^{1

2}, Yoshihide Matoba¹, Makiko Mukumoto¹, Yoshiaki Nakagawa², Hisashi Miyagawa²

Affiliations

¹ Sumitomo Chemical Co., Ltd. Environmental Health Science Laboratory, 1-98 Kasugadenaka, 3-chome, Konohana-ku, Osaka 554-8558, Japan.
² Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.

Abstract

The ability to predict the environmental behavior of chemicals precisely is important for realizing more rational regulation. In this study, the bioaccumulation of nine chemicals of different molecular weights absorbed via the intestinal tract was evaluated in fish using the everted gut sac method. The amounts of chemicals that passed through the intestinal membrane after a 24-hr exposure were significantly decreased for chemicals with MW≥548 and D_{max min}≥15.8 Å (or D_{max aver}≥17.2 Å). These thresholds are consistent with those previously proposed in terms of MW (>800) and molecular size (D_{max min}>15.6 Å or D_{max aver}>17.1 Å) for the limit of permeable chemicals through the gill membrane. The results show that the same MW and D_max criteria can be used to predict low bioaccumulation through both the gill membrane and the intestinal tract. These findings are helpful in reducing the need to conduct animal tests in environmental safety studies.

Keywords: bioaccumulation; everted gut sac method; fish intestinal membrane; permeability.

© Pesticide Science Society of Japan 2022. This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License (https://creativecommons.org/licenses/by-nc-nd/4.0/).