Targeted drug release system based on pH-responsive PAA-POSS nanoparticles

Won Jung Kim; Eu Hyun Lee; Yong-Jin Kwon; Sang-Kyu Ye; Kyu Oh Kim

doi:10.1039/d2ra01141g

Targeted drug release system based on pH-responsive PAA-POSS nanoparticles

RSC Adv. 2022 Jun 22;12(28):18209-18214. doi: 10.1039/d2ra01141g. eCollection 2022 Jun 14.

Authors

Won Jung Kim¹, Eu Hyun Lee¹, Yong-Jin Kwon², Sang-Kyu Ye², Kyu Oh Kim¹

Affiliations

¹ Department of Fiber System Engineering, Dankook University 152, Jookjeon-ro, Suji-gu Yongin-si Gyeonggi-do 448-701 Republic of Korea.
² Department of Pharmacology, Seoul National University College of Medicine Republic of Korea sangkyu@snu.ac.kr.

Abstract

An amphipathic PAA-POSS@DOX drug delivery system that responds sensitively to pH changes in the cancer microenvironment has been developed using a nanoparticle based on inorganic polyhedral oligomeric silsesquioxane (POSS). POSS was introduced to the carboxylic acid group of polyacrylic acid to which doxorubicin anticancer drug was loaded to prepare 480 ± 192 nm self-assembled nanoparticles. PAA-POSS had a high loading efficiency of over 75% and doxorubicin was quickly released to the target area responding sensitively to weakly acidic conditions. The possibility of employing PAA-POSS as a targeted drug delivery system has been confirmed by observing the death of cells of the MDA-MB-231 breast cancer line.